The genetic predisposition to severe COVID-19


Genomic analyses of critically ill COVID-19 patients in Sweden. 

Karolinska Institutet

171 77 Stockholm, Sweden

Uppsala University

752 36 Uppsala, Sweden

Publications

  • Mapping the human genetic architecture of COVID-19. The COVID-19 Host Genetics Initiative. Nature. Online July 8, 2021.

  • A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M, Kerrison N, Zhao K, Brunet-Ratnasingham E, Henry D, Kimchi N, Afrasiabi Z, Rezk N, Bouab M, Petitjean L, Guzman C, Xue X, Tselios C, Vulesevic B, Adeleye O, Abdullah T, Almamlouk N, Chen Y, Chassé M, Durand M, Paterson C, Normark J, Frithiof R, Lipcsey M, Hultström M, Greenwood CMT, Zeberg H, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE, Richards JB. Nature Medicine. 2021 Apr;27(4):659-667.

  • Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Nafría-Jiménez B, Bouysran Y, Niemi M, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitano S, Tato LR; FinnGen; COVID-19 Host Genetics Initiative, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales J, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Bujanda L, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A. PREPRINT

  • A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Zeberg H, Pääbo S. PNAS. 2021 Mar 2;118(9).

  • The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.  Zeberg H,Pääbo S. Nature. 2020 Nov;587(7835):610-612


Scientists


Hugo Zeberg

MD/PhD, asst. prof.

Miklós Lipcsey

MD/PhD, prof.

Robert Frithiof

MD/PhD, assoc. prof

Michael Hultström

MD/PhD, assoc.prof.

Jonathan Grip

MD/PhD

Nicolas Tardif

PhD, asst. prof


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